International Society for Stem Cell ResearchMar 5 2026 Researchers have found that targeted delivery of messenger RNA (mRNA) can restore sperm production and fertility in genetically infertile male mice. The findings, published today in Stem Cell Reports, demonstrate that transient mRNA treatment restored sperm production and enabled the birth of healthy offspring. Up to 10% of couples worldwide are affected by infertility, according to World Health Organization estimates, and male factors are the primary cause in about half of those cases. In many instances, male infertility results from genetic defects that disrupt sperm production. To develop a targeted method to address genetic defects linked to infertility, Takashi Shinohara of Kyoto University, Japan, and his team injected mRNA – a short-lived molecule containing the blueprint of a gene of interest – into the testes of mice. The use of mRNA was specifically chosen to avoid permanent genetic modification of testis cells or other cells in the body. The researchers first confirmed that this approach successfully delivered the genetic blueprint to the relevant cell types – sperm-producing cells and supporting Sertoli cells in the testis. They then tested whether mRNA delivery could restore fertility in male mice carrying a specific genetic defect in Sertoli cells that blocks sperm production. This defect has also been implicated in human infertility and testicular disorders. Related StoriesTiny DNA junctions provide feedback to control genetic crossoversGender-affirming hormone therapy rewrites body proteins to match gender identityNatural ovulation matches hormone therapy success in frozen embryo transferDelivery of mRNA, which remained active for two days, was sufficient to unblock spermatogenesis in these genetically infertile mice. Importantly, sperm collected from treated animals generated healthy pups when injected into mouse oocytes by in vitro fertilization. This work demonstrates that mRNA delivery can rescue a specific genetic defect underlying male infertility in mice. Additional studies in animal models will be required to evaluate safety and efficacy before considering potential clinical applications in human patients. Source:International Society for Stem Cell ResearchJournal reference:Kanatsu-Shinohara, M., et al. (2026). Messenger RNA delivery into Sertoli cells restores fertility to congenitally infertile male mice. Stem Cell Reports. DOI:10.1016/j.stemcr.2026.102829. https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(26)00040-8

当所有智能体都在“少数服从多数”时，错误也可能被投票放大。但如果不再追求共识，会发生什么？一项研究结果显示，仅通过单轮协作，无需达成共识，多智能体协同反而能实现更高的准确性、效率和鲁棒性。这个有些“反直觉”的结论，来自浙江清华长三角研究院信息技术研究所张海滨教授团队（通讯作者）与北京理工大学团队近期合作的研究，他们研发出一种多智能体协作架构 Free-MAD，打破了多智能体辩论必须“达成共识”的铁律。在多项任务评测中，Free-MAD 在显著降低硬件资源需求的同时，无需达成共识，仅通过单轮协作，能高效组合数个（中小型）开源大模型，在部分复杂任务方面超越国际主流单体大参数模型（如 Gemini 3、GPT-5.2）的性能水平。图丨张海滨团队（来源：受访者）近年来，多智能体协同正成为提升大模型推理能力的热门方向之一，Anthropic、月之暗面等机构也在关注该方向。传统方法中大模型特有的从众机制是，哪怕是错误的观点也要“少数服从多数”。另一方面，传统多智能体协作方案通常需要两至三轮交互才能达成共识，这会导致模型的准确率和性能均不高，并且费时费钱。该方案摒弃了传统方法，基于奖励评分决策机制评估整个辩论轨迹，而非仅依赖最后一轮结果；同时通过抗从众机制，使智能体有效识别并避免从众错误推理的传播。与传统方法相比，在该框架下仅需单轮多智能体交互，即可实现与传统方法的推理相当的效果；在对抗环境下，具有更强的鲁棒性、较低的推理开销以及更高的可拓展性。该研究为在算力受限环境下实现高性能模型应用，提供了一种兼具成本和性能的技术路径。对工业界而言，意味着可部署更轻量、更便宜、更安全的 AI 协作系统；对学术界而言，它开启了“非共识化多智能体系统”的新方向。图丨相关论文（来源：arXiv）参数堆砌之外的突破：多智能体协作的效率革命当前，全球大模型技术发展呈现出明显的结构性不平衡。一方面，国际上先进的大模型，例如谷歌的 Gemini、OpenAI 的 GPT 以及 Anthropic 的 Claude Opus 系列等仍以闭源为主。尽管在性能和通用能力方面具有优势，但受到技术封锁、合规限制及地缘政治因素等影响，其难以实现广泛获取与使用。另一方面，国内开源模型在透明性、可审计性和自主可控方面具备优势，但不容忽视的一个问题是，其在综合性能、复杂任务处理能力等关键指标上，与顶尖闭源模型仍存在一定的差距。实际部署层面的挑战同样严峻，现有部分 200B 及以上参数规模的大模型（如 DeepSeek-V 系列、Qwen 高参数版本等）往往高度依赖多张 NVIDIA H200 级 GPU 硬件，单卡成本较高，这对整体算力来说是一项较高的支出。相比之下，轻量级小参数模型，例如 32B 级开源模型可在多张 NVIDIA 4090 级别的消费级显卡环境下完成部署，但它的局限性在于单模型能力在复杂任务场景和应用深度方面受限。图丨基于分数的 Free-MAD 协议及其评价（来源：arXiv）在此背景下，研究团队开发了全新多智能体协作架构 Free-MAD。为有力抑制答案的“盲目跟风”，研究人员引入了反从众的机制来重构辩论阶段。通过鼓励批判性思维，系统可实现主动降低对多数意见的敏感度。张海滨对 DeepTech 解释道：“不能为了达成共识而达成共识，而是应该去思考问题的本身。每个大模型或智能体都会产生自己的思考结果，其不仅要收到对方的结果来做决定，更重要的是，要用批判性思维来看待对方的推理过程是否合理。”在决策阶段，研究团队基于纯算法逻辑引入了奖励评分决策机制，来评估整个辩论轨迹。这样，最终决策并非取决于最后一轮“谁声量高听谁的”，而是通过全程追踪辩论过程中所有智能体的每次推理轨迹变化。（来源：arXiv）这种决策逻辑带来的好处是，无需在辩论阶段达成共识，即便正确答案在末轮未获得多数投票，系统仍可能基于它在辩论过程中的稳定表现或合理转变而获得结论。除了开发全新的推理框架，这项研究还揭示了多智能体协同中有趣的现象：有的场景下，异构模型的效果强于同构模型；但其他场景下，同构模型反而更强，甚至对应不同的工作或者任务，需要动态调整核心算法与参数。对于非专业的用户来说，Free-MAD 无异于通用大模型或智能体应用，而针对专业用户，研究团队在此基础上进行参数调优，进化出高度优化的通用版本 MAX-MAD，使性能和准确率进一步提升，以应对不同的场景和赛道。“参数调优的好坏直接关系到准确性，甚至关系到整个共识达成的速度。因此，我们设置了额外的一些重要的参数调优。”该论文第一作者崔宇对 DeepTech 表示。据悉，该系统前置了三个重要模块：针对输入任务的分类（例如数学、推理、哲学，或其他问题）等，对任务复杂度评估以及策略参数优化器。此外，研究人员还开发了智能体的自适应模块以及反馈机制的收集。破解大模型协作中的从众难题在实验部分，研究团队的测试覆盖了 8 个数据集，包括数学推理（GSM-Ranges、AIME2024、AIME2025 和 MATH500）、逻辑推理（StrategyQA 和 MMLU 的逻辑谬误数据集）、知识和理论推理（AICrypto 的多选题数据集）等。据团队介绍，在综合数学推理测试中，研究人员综合使用国内的四大开源模型组合（Qwen3-235B、DeepSeek-V3.2、Kimi-K2 和 GLM-4.7）以及调用同一个国产大模型的单一组合（以上任意一种大模型， 如 Qwen3-235B）。综合来看，Free-MAD 和 MAX-MAD 通过多智能辩论后，能够达到约 86.67%-90% 的准确率，不仅将四个单体模型本身的准确率大幅提升了 15-30%，更值得关注的是，该准确率也超过了主流闭源模型（如 Gemini 3、GPT-5.2）在相同数据集上的公开成绩。（来源：arXiv）基线方法采用了被广泛采用的多智能体辩论框架 SoM，结果显示，Free-MAD-N（反从众辩论+评分决策）在单轮辩论（R=1）时准确率达 64.43%，比基线 2 高近 10%，比基线 1 高近 19%。值得关注的是，基线方法在单轮辩论时效果不佳，单轮无法形成共识；而 Free-MAD 不需要共识，单轮结果优于基线两轮成绩。图丨在不同辩论轮次下，比较 Free-MAD 方案与基线方案在 token 消耗和推理准确度方面的差异（来源：arXiv）从 token 消耗结果来看，Free-MAD 或 MAX-MAD 的轮数由原来的两三轮变成现在的单轮，相当于整个 token 的使用量或带宽的使用量降为原来的一半。“这也是一项重要的成本节省。”张海滨说道。在安全性方面，研究团队也进行了相关设计。智能体往往涉及到多智能体协作，50% 智能体被断网时，基线准确率会下降 15%-20%。因此，需要考虑的情况是：万一部分智能体无法正常工作，或系统的一部分不工作的情况，是否能保障系统的安全性，以及是否仍能够按时获得输出结果。经过研究人员测算，Free-MAD 或 MAX-MAD 系统在抵御宕机或通信攻击情况下的表现较为理想。实验结果显示，即便智能体（短暂）离线，或受到敌手攻击，不能把自己的信息发送情况下，其余的智能体也能准确地完成任务。从实验室走向产业：多智能体协作的落地路径据研究团队介绍，来自研究社区的英国独立研究团队已基于该成果复现了 Free-MAD。值得注意的是，相关团队将包括权重在内的所有系统超参数设为自适应可配置，并引入了基于归一化的方法及若干额外工程化策略，显著提升了系统的实用性与并行能力。这种兼具安全性和性能优势的框架有望用于高质量推理内容生成，以及智慧医疗、舆情治理、金融分析等高安全敏感应用领域。在高质量内容生成领域，基于框架较强的通用性，该方案可直接用于任意大模型和智能体进行传统的智能问答。尽管它在结果返还速度上相对传统大模型较慢，但基于辩论优化逻辑链，可大幅度提升政策解读、行业报告等文本的专业性与可信度。在智慧医疗领域，该成果有望模拟心内、影像、病理等多科室专家会诊，甚至产生辩论，来对疑难病症进行诊断。例如，三个智能体分别对患者病情进行评估，在其中两个智能体误判为良性，一个智能体坚持是恶性的情况下，传统的 MAD 方法有可能因为共识压力输出错误的结果，而该方案能通过特有的轨迹分析，识别出少数派的扎实推理理念，进而做出更精准的评估。在舆情治理方面，可构建虚拟的辩论社区，多角度解构舆情领域的脉络，实现风险的早识别、早干预。目前，在汽车舆情的治理方面，研究团队已经有相关落地案例。张海滨指出，“从结果来看，通过辩论得到的结果，明显优于单模型或传统共识型多智能体方案。”在金融分析领域，多 Agent 协同有利于更好地研判市场信号，生成逻辑严密的投资策略和风控报告。图丨张海滨（来源：受访者）张海滨教授目前担任浙江清华长三角研究院信息技术研究所所长、学术带头人，其团队致力于为 AI 提供从数据层、模型层到应用层的完善解决方案。该团队承担多项国家级与省部级科研项目，例如“天枢·可信数据空间”。围绕可信数据空间与多智能体协同架构展开研究，并落地大小模型协同的“天迹·工业智能体”。相关成果已在能源、电信、国家电网、国家管网等领域落地，并参与包括央行数字货币等在内的多边金融基础设施项目建设。在未来的研究中，该团队计划构建新一代策略参数优化的更高性能、更准确的多智能体协作框架。目前，他们正在探索将该框架与硬件系统结合的可能性，旨在通过硬件优化解决多智能体辩论中分词、解码及广播带来的带宽消耗和延迟问题。在算力成为瓶颈的时代，或许这类架构创新比单纯堆参数更具战略意义。参考资料：1.Yu Cui, Hang Fu, Haibin Zhang, Licheng Wang, Cong Zuo, Free-MAD: Consensus-free multi-agent debate, arXiv preprint arXiv:2509.110352.系统已开放内测，感兴趣的读者可邮件联系李老师： likang@tsinghua-zj.edu.cn运营/排版：何晨龙

University of British ColumbiaMar 5 2026 About one in 20 infants worldwide is subjected to physical abuse by a caregiver in their first two years of life. That's the central finding of a new study co-led by researchers from the UBC faculty of medicine and Memorial University of Newfoundland (MUN), the first to bring together anonymous reports from caregivers about behaviors like spanking, slapping, shaking and hitting. About four to five per cent of parents are behaving in physically aggressive ways toward their babies. This should give us all pause and make us think about interventions that could shift behavior." Dr. Nichole Fairbrother, clinical associate professor in UBC's department of family practice and head of the Perinatal Anxiety Research Lab Infants are entirely dependent on their caregivers, making them especially vulnerable to physical aggression that can arise in many circumstances-sometimes in moments of stress for overtired caregivers, but also within families facing other challenges such as mental health difficulties or existing violence in the home. While some still view spanking or wrist slapping as 'discipline', such behaviors can have lasting effects on a child's learning, behavior and mental health. Evidence has linked these actions with harm and with a higher chance of more severe violence in the future. Understanding how common these kinds of behaviors are could help health systems, policymakers and families focus on prevention, getting support to parents before a bad moment turns into injury. Dr. Fairbrother, co-lead author Cora Keeney, MUN's Dr. Jonathan Fawcett and their collaborators reviewed 20 studies that together encompassed reports on more than 220,000 infants and caregivers across several countries. When caregivers were asked privately and anonymously, 4.8 per cent reported at least one act of physical aggression toward an infant under 24 months. Rates were slightly lower when "milder" actions like spanking were excluded (3.9 per cent), but the picture stayed the same: This is common, and mostly hidden. The study helps explain why official statistics often look lower. Most child‑protection records capture only the most serious incidents that someone else notices and reports. "Anonymous surveys let caregivers disclose behavior that never reaches a clinic, police service or social worker," said Dr. Jon Fawcett, an assistant professor at MUN who co-led the research. "By pooling these studies, we can estimate what's really happening at a population level, not just what gets detected." Related StoriesMental health conditions post-cancer diagnosis linked to higher mortality riskStudy highlights the mental health costs of marine ecosystem damageProblematic gaming in pre-teens linked to higher risk of psychotic experiencesThe researchers also looked at specific actions. Shaking occurred at a low yet noteworthy prevalence, around two to three per cent in estimates. Spanking was more common in some samples. The authors point to a mix of practical supports and policy steps that could help address the issue. Parenting an infant is stressful-sleep loss, constant crying, money worries-and stress can push even calm caregivers into moments of frustration when they react in ways they normally wouldn't. Simple, well‑timed education for new parents such as what to do when crying peaks, easy‑to‑reach support lines and home‑visiting programs could help. Clear policies that set the norm against hitting children also matter. Countries that prohibit physical punishment send a consistent message that violence has no place in caregiving. This area of study still needs better and broader data, especially from regions that are under‑represented. More studies would also allow researchers to explore important details, such as whether rates differ by a baby's age or by caregiver characteristics, so prevention efforts can be targeted where they're most needed. "Infancy is the most vulnerable stage of life, and many cases of physical aggression never show up in official counts," said Dr. Fairbrother. "Knowing the true scope is the first step toward stopping it." The research was published Wednesday in eClinicalMedicine, a Lancet journal. Source:University of British ColumbiaJournal reference:Keeney, C. L., et al. (2026). Prevalence of physical abuse by caregivers toward infants aged 0–24 months: a systematic review and meta-analysis. eClinicalMedicine. DOI: 10.1016/j.eclinm.2026.103812. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(26)00059-3/fulltext

Cell PressMar 5 2026 Accumulation of the protein tau in the brain is one of the hallmarks of Alzheimer's disease. In a paper publishing March 5 in the Cell Press journal Cell Press Blue, researchers report a previously unknown mechanism that appears to enable the build-up of tau. The study, which employed animal and cellular models as well as patient tissues, suggests a key role for tanycytes-specialized brain cells that regulate brain-body signaling. Our findings reveal a previously underappreciated, disease-relevant role for tanycytes in neurodegeneration. Focusing on tanycyte health could be a way to improve tau clearance and limit disease progression." Vincent Prevot, corresponding author, INSERM, France Tanycytes are a type of non-neuronal brain cell that are primarily found in the third ventricle of the brain. Previous research has shown that these cells play an active role in shuttling metabolic signals between the blood and the cerebrospinal fluid (CSF)-the liquid that surrounds the brain and spinal cord and acts as a communication hub for maintaining homeostasis. In this study, the researchers sought to better understand how tanycytes clear toxic molecules such as tau to preserve brain health. They found that the brain cells carry toxic molecules out of the CSF and into the blood for disposal, and that when they don't work properly, tau can accumulate in the brain. "Surprisingly, we were able to show in rodent and cellular models not only that tanycytes were indeed involved in clearing tau but also that tanycytes in the brains of human Alzheimer's patients were fragmented and had changes in gene expression related to this shuttle function," Prevot says. Related StoriesInnovative laser procedure offers new hope for recurrent brain tumorsScientists put forward a new theory of brain developmentResearchers reveal why SuperAgers retain youthful brain cell signatures into their 80sThe team says these findings highlight the potential of developing interventions aimed at maintaining brain homeostasis to prevent neurodegeneration but acknowledge several challenges to targeting tanycytes as a way to develop interventions for Alzheimer's. One key limitation is the lack of good animal models for Alzheimer's disease. Another is the need for larger cohorts and more longitudinal data to establish causality and define the sequence of events linking tanycyte dysfunction to tau pathology. "Our findings provide the first evidence for structural and functional alterations in these little-known but key brain cells in human disease," says Prevot. This work was supported by the European Research Council, National Institutes of Health, the Fondation pour la Recherche Médicale, and the Fondation NRJ for Neuroscience-Institut de France. Source:Cell PressJournal reference:Sauvé, F., et al. (2026). Tanycytic degeneration impairs tau clearance and contributes to Alzheimer’s disease pathology. Cell Press Blue. DOI: 10.1016/j.cpblue.2026.100003. https://www.cell.com/cell-press-blue/fulltext/S3051-3839(26)00001-0

University of TorontoMar 5 2026 The study is among the first to examine strengths-based indicators of well-being in a large, population-level Indigenous sample. Healthy functioning was significantly associated with never smoking, being physically active, having fewer chronic health conditions, and meeting basic financial needs. These results challenge deficit-focused narratives that blame individuals or groups rather than policies, socioeconomic conditions, and other structural issues. Instead, they underscore the value of identifying factors that support thriving in Indigenous communities. Understanding wellness among Indigenous Peoples requires recognizing both the structural barriers created through colonization and the remarkable strengths our communities continue to embody. Our findings highlight that Indigenous adults can experience meaningful well-being despite longstanding inequities." Ashley Quinn, First Author, Assistant Professor in the Factor-Inwentash Faculty of Social Work (FIFSW), University of Toronto The study, which drew on data from the 2022 and 2023 Behavioral Risk Factor Surveillance System (BRFSS), also found strong connections between socioeconomic stability and healthy functioning. Respondents who could reliably pay their bills or access transportation had substantially higher odds of meeting the study's well-being criteria. "Financial security is not simply an economic indicator-it is a health determinant," said co-author Teagan Miller, a recent Master of Social Work graduate from the FIFSW. "Stable access to food, transportation, and housing meaningfully increases the likelihood of healthy functioning, which reinforces the need for policy interventions that address systemic inequities." Chronic physical and mental health conditions were key predictors of lower healthy functioning. Notably, respondents without depression had more than four times the odds of meeting positive well-being criteria compared to those with depression. Related StoriesStronger connection found between cannabis use and mental illnessShort-duration psychedelic therapy shows promise for major depression treatmentFive sessions a day TMS approach may reduce depression symptoms in one week"Mental health cannot be separated from community, family, land, and cultural identity," said co-author Philip Baiden, an Associate Professor in the School of Social Work at the University of Texas at Arlington. "Interventions that incorporate Indigenous worldviews are essential to supporting emotional wellness and healing." Healthy behaviors-including avoiding smoking and engaging in regular physical activity-also played a significant role. More than half of respondents had never smoked, and roughly three-quarters were physically active. "This study flips the script-shifting the narrative from deficits to the strengths and resilience of Indigenous Peoples," said co-author Esme Fuller-Thomson, a Professor at FIFSW and Director for the Institute of Life Course and Aging at the University of Toronto. "Healthy functioning among Indigenous Peoples is not rare-it's real, measurable, and deeply shaped by social and economic conditions." The authors note that while nearly 30% of Indigenous respondents were functioning healthily, two-thirds did not meet the study criteria-indicating a need for expanded public health initiatives that address both structural inequities and culturally meaningful pathways to wellness. This research contributes to a growing field that emphasizes Indigenous strengths, resilience, and wholistic wellness rather than focusing solely on disparities. The authors call for future studies that incorporate Indigenous-defined measures of health, including community, cultural, spiritual, and environmental dimensions. This research was published recently in the Journal of Indigenous Well-Being. Source:University of TorontoJournal reference:Quinn, A., et al. (2026) A Closer Look at Flourishing Indigenous Peoples: Findings from a Population-Based Study. Journal of Indigenous Well-Being. https://journalindigenouswellbeing.co.nz/journal_articles/a-closer-look-at-flourishing-indigenous-peoples-findings-from-a-population-based-study/

Washington University in St. LouisMar 5 2026 The brain relies on real-time delivery of oxygen and nutrients through its microvasculature, which threads through neural tissue like electrical wires. While modern imaging technologies allow researchers to follow the activity of individual neurons in the brain, they are not yet advanced enough to dissect the microvascular function at a comparable spatial scale. This gap hinders our understanding of cerebral small vessel disease and its contributions to cognitive impairment and dementia. To address this challenge, a team of researchers at Washington University in St. Louis and Northwestern University, led by Song Hu, professor of biomedical engineering in the McKelvey School of Engineering, has developed super-resolution functional photoacoustic microscopy (SR-fPAM). By tracking the movement and oxygenation-dependent color change of red blood cells, SR-fPAM allows researchers to image blood flow and oxygenation at single-cell resolution in the mouse brain, which bridges a critical gap in functional microvascular imaging and could provide new insight into microvascular health and disease, such as stroke, vascular dementia and Alzheimer's disease. Results of the research were published March 3, 2026, in Light: Science & Applications. Red blood cells, which are abundant in blood vessels, naturally absorb light due to hemoglobin, the molecule responsible for oxygen transport. When illuminated with short laser pulses, hemoglobin generates ultrasound waves, a phenomenon known as the photoacoustic effect. While conventional photoacoustic microscopy can image blood vessels without labeling them, it does not provide single-cell resolution in 3D. Hu's team addressed this limitation by developing a high-speed photoacoustic microscope capable of repeatedly imaging the same brain region at millisecond intervals, allowing them to trace red blood cell movement in single files through capillaries and in groups through larger vessels. By tracking these cells across sequential frames and accumulating their trajectories computationally, the researchers were able to reconstruct 3D microvascular structures at single-cell resolution. Similar to super-resolution fluorescence and ultrasound imaging, SR-fPAM leverages high-speed imaging to track dynamics and uses that information to identify features that are smaller than the conventional resolution limit. We condense multiple spatiotemporally acquired frames into a single one with substantially improved resolution." Song Hu, professor of biomedical engineering, McKelvey School of Engineering In their experiments, SR-fPAM revealed how blood flow and oxygenation redistributed across 3D microvascular networks in the brain after an induced stroke. When a single microvessel was occluded, nearby vessels instantly changed their flow patterns, redirecting red blood cells to help sustain oxygen delivery to the affected tissue "When one vessel is blocked, red blood cells take alternative routes to continue the flow and oxygen supply," Hu said. "Using SR-fPAM, we can observe not only structural changes in the 3D microvasculature, but also how fast red blood cells move, how their flow directions change, and how they release oxygen into the surrounding tissue in response to stroke-induced ischemia." Related StoriesBlood test models predict when Alzheimer’s symptoms may start years in advanceNearly 70 weeks after infection, long COVID patients show no detectable inflammation in blood testsExtreme endurance exercise pushes red blood cells toward accelerated agingLooking ahead, Hu and his team want to pair SR-fPAM with two-photon microscopy so that we can simultaneously image both red blood cells and neurons at single-cell resolution. "This would allow us to study how neurons and microvessels are spatiotemporally coordinated with each other and how their dynamic coupling gets disrupted in disease," Hu said. "It may also help us better interpret clinical neuroimaging techniques, such as functional MRI, which infers brain activity from vascular signals. Hu said this work could have a significant translational impact. "Cerebral small vessel disease is increasingly recognized as a leading cause of cognitive impairment and dementia, and WashU is at the frontier of this in both basic and clinical research," Hu said. "If we can better understand how microvascular oxygenation and flow change in the early stages of disease, it may help guide the development of early detection strategies and therapeutic interventions." Source:Washington University in St. LouisJournal reference:Zhong, F., et al. (2026). Super-resolution functional photoacoustic microscopy via label-free cell tracking. Light: Science & Applications. DOI: https://doi.org/10.1038/s41377-026-02235-3. https://www.nature.com/articles/s41377-026-02235-3

University of LimerickMar 5 2026 A study from University of Limerick in Ireland has identified the hidden challenges of women living with and managing Gestational Diabetes Mellitus (GDM). The research led by academics in UL's Department of Psychology is the first review of the evidence in this area. It highlights specifically how partners influence the experiences of women diagnosed with GDM. According to the research, which analysed the experiences of almost 2,000 women across 21 countries, partners play an important role in women's experiences of GDM, but support is not always helpful, and the level of support provided varies widely. The extensive review titled: 'Partners' influences on women's experiences of living with and managing Gestational Diabetes Mellitus: A Qualitative Evidence Synthesis,' analysed 62 qualitative studies and was recently published in Health Psychology Review. GDM is the most common pregnancy-related complication and can affect both mother and baby, potentially leading to long-term health implications. According to Diabetes Ireland, the condition affects roughly 7,000 pregnancies, which corresponds to between 12–14% of pregnancies in Ireland annually. Findings revealed that supportive partners appeared to positively influence coping and management of the condition, while overbearing or inadequate support increased the burden of GDM for the women. Lead author of the study, Fay O'Donoghue, led the review as part of her PhD research at University of Limerick. Ms O'Donoghue said: "For many women in Ireland and around the world, the day-to-day reality of gestational diabetes is shaped not only by clinical care but also by what happens at home, including the role of partners." The study revealed several key findings: When partner support meets women's wants and needs, the support can help them cope and manage the condition day to day When support is insufficient, it can increase pressure and emotional strain, making managing the condition more difficult Women's preferences for partner involvement varied, and support worked best when it matched their specific needs Monitoring or "surveillance" by partners could be helpful (providing accountability or structure) or intrusive, depending on the woman Mismatched support left women feeling unsupported or frustrated Related StoriesCombining healthy lifestyle and GLP-1 therapy reduces heart risks in diabetesGut bacteria patterns help predict insulin resistance in type 2 diabetes, study findsMetformin linked to lower odds of intermediate macular degeneration in people with diabetesOverall, the effectiveness of partner support depends on knowledge, communication, alignment with women's individual needs, and cultural context. "Our findings highlight the importance of ensuring partners have the right knowledge and understanding of gestational diabetes, so they can provide supportive, collaborative, and individualized help", said Ms O'Donoghue. "Open communication between couples is also essential, allowing partners to understand women's needs and offer the right kind of support," she added. Cultural expectations around support also impacted how support was perceived and provided. The authors recommend that healthcare strategies focus on improving opportunities for GDM education and culturally tailored support to optimise partner involvement. Future research to explore factors influencing support and identify strategies to enhance GDM care was also recommended. Involving partners more substantively in gestational diabetes care could lessen the burden on women and support healthier pregnancies." Dr. Ann-Marie Creaven, Associate Professor in Psychology, and review co-author Dr Tomás Patrick Griffin, Consultant in Diabetes, Endocrinology and General Internal Medicine, and co-author explained that, while GDM often resolves after birth, "women who experience it are at higher risk of developing type 2 diabetes later, and their children may face increased risks of overweight and diabetes". Dr Griffin said: "Our study shows that the support women receive at home can make a real difference in how they manage the condition and cope with the stress it brings." "The implications are clear: partner-inclusive education and culturally informed care plans could improve everyday management and reduce the psychological burden of GDM," added Dr Griffin. Source:University of LimerickJournal reference:O’Donoghue, F. M., et al. (2026). Partners’ influences on women’s experiences of living with and managing gestational diabetes mellitus: a qualitative evidence synthesis. Health Psychology Review. DOI: 10.1080/17437199.2026.2623886. https://www.tandfonline.com/doi/full/10.1080/17437199.2026.2623886

原标题：美媒：美军担忧防空拦截弹库存不足 据美国《华尔街日报》网站3月1日报道，当美国军方最高将领向特朗普总统罗列对伊朗发动大规模长期攻击的风险时，他指出的问题之一是美国的弹药储备。 现任和前任官员及分析人士表示，这一点正在经受考验：美国争分夺秒，要赶在抵御伊朗报复的拦截弹耗尽之前摧毁伊朗的导弹和无人机力量。 美国防空拦截弹库存的确切规模——五角大楼称之为“弹药库深度”——一直是保密的。 但是，与伊朗及其中东代理人的多次冲突不断消耗着美国在该地区的防空弹药。 从德黑兰时间2月28日上午开始，美国及以色列对伊朗领导人和军事目标(包括伊朗的导弹发射器、无人机和机场)实施了轰炸。一名高级官员当天说，美以率先发动袭击的原因之一，是要削弱伊朗用导弹和无人机展开报复的能力。 伊朗在去年6月的“12日战争”期间发射了500多枚导弹和大量的攻击型无人机。该国28日的报复行动更为猛烈。 尽管如此，美军中央司令部28日说，美军基本上成功防御了伊朗的数百次导弹和无人机袭击，尽管有些导弹和无人机命中了目标，特别是在靠近伊朗的海湾国家。这场冲突尚未结束，美国、以色列和伊朗还会发动更多袭击。 美国智库史汀生中心的高级研究员凯利·格里科说：“其中一个挑战是，你可能很快就会耗尽这些弹药。我们的使用速度超过了补给速度。” “萨德”反导系统于2024年与操作该系统的美国陆军部队一起部署到以色列，当时拜登政府试图保护该国免受伊朗的攻击。约旦也部署了一套“萨德”系统。五角大楼的主要忧虑之一是能否为“萨德”系统维持充足的拦截弹库存。 五角大楼还在加紧补充“爱国者”导弹和“标准”导弹的库存。 这两种拦截弹也能消除空中威胁，正在用于防御伊朗的导弹和无人机。“爱国者”导弹消灭低空威胁，“标准”-3型导弹则可以拦截大气层以外的弹道导弹。 防空拦截弹不是唯一短缺的弹药。美国还动用海基“战斧”巡航导弹和空基武器，对伊朗目标实施了打击。 以色列军方的参与将缓解美国在进攻性弹药供应上的压力。但以色列也对其弹药供应感到担忧，它的“箭”-3防空拦截弹数量仍然不足，空射弹道导弹也不多。 一名美国官员说，如果战争持续下去并需要更多的拦截弹，五角大楼将决定是否动用太平洋地区的库存。（编译/葛雪蕾）

5日，谷歌DeepMind开发体验负责人奥马尔·桑塞维耶罗发文称：“千问的朋友们如果想找个新东家来打造优秀模型，并为开源模型生态系统做出贡献，请随时联系我！我们的路线图中有很多令人兴奋的事情，前方还有许多工作等待我们去做。”阿里巴巴今日已批准通义实验室林俊旸的辞职申请。阿里巴巴CEO吴泳铭在内部邮件中回应林俊旸离职一事，他表示，发展基础大模型是面向未来的关键战略，将在继续坚持开源模型策略的同时，持续加大对人工智能领域的研发投入，加大吸纳优秀人才的力度。3月3日，阿里巴巴开源4款小尺寸千问3.5系列模型。其中最小的0.8B和2B两款，体积极小，推理速度极快，适合移动设备、IoT 边缘设备部署，以及低延时的实时交互场景。据悉，四款Qwen3.5新模型虽是小尺寸，但均拥有原生多模态能力，以极小的参数量实现了极大的性能提升。模型发布后还迅速引来马斯克在社交媒体上点赞评论，称阿里千问模型“智能密度令人印象深刻”。

3月5日，十四届全国人大四次会议首场“部长通道”集中采访活动在人民大会堂举行，工业和信息化部部长李乐成就当前我国人工智能产业发展形势及如何推动人工智能创新发展回答了记者提问。今年《政府工作报告》多次提到“人工智能”，提出要深化拓展“人工智能+”，促进新一代智能终端和智能体加快推广，推动重点行业领域人工智能商业化规模化应用，培育智能原生新业态新模式。支持人工智能开源社区建设，促进开源生态繁荣。实施超大规模智算集群、算电协同等新基建工程，加强全国一体化算力监测调度。深化数据资源开发利用，健全数据要素基础制度，建设高质量数据集。完善人工智能治理。对此，李乐成表示，今年春晚，人形机器人“组团炫技”，成为全网热议的“顶流”，机器人舞台上所呈现的不只是“武术”和“才艺”，而是中国人工智能从科技攻关走向场景落地亮出的“中国功夫”，是中国人工智能产业创新发展的精彩亮相，是新质生产力走进大众视野的生动展示。人工智能这个“关键变量”，正成为经济高质量发展的“强劲增量”。李乐成指出，2025年，中国人工智能核心产业规模超过1.2万亿元，企业数量超过6200家，总体看有三大亮点。第一，中国大模型走向世界。去年，中国企业推出的开源大模型下载量全球第一，大幅降低了人工智能的使用门槛，降低了使用成本，增强了人工智能的普惠性，国产开源大模型引领全球开源生态。第二，AI工具赋能生产。截至2025年底，我国规上制造业企业人工智能技术应用普及率超30%，无人产线、人机协同在车间、在工厂成为“潮流”，极大提升了设计、制造和质量检验等各环节质效。第三，智能终端走进人们生活。AI眼镜、AI手机、AI电脑等潮品、爆款不断涌现，走进千家万户。国内企业推出300多款人形机器人，超过全球半数。李乐成指出，2026年，工信部将按照《政府工作报告》要求，大力推动人工智能和制造业双向奔赴，着力做好三个方面的工作。第一，依托产业优势，做优产品供给。我国产业门类齐全、创新人才众多，创新生态不断改善，我们坚信必将有更多的世界级智能产品在这片热土上生产出来。要努力推动AI电脑、AI手机、智能家居更好满足人民群众对美好生活的需求。要全力推进新一代人工智能产品，包括脑机接口、自动驾驶汽车、人形机器人的科技攻关、技术迭代。要大力支持发展智能农业机械、智能医疗器械，让更多智能产品满足各行业各领域的需要。第二，立足场景优势，做深行业应用。“人工智能+制造”是一个必答题，不是一个选择题。要大力推动“人工智能+制造”，制造业的各行各业都要拥抱人工智能，深度挖掘高价值应用场景，培育一批高水平典型应用，打造一批特色智能体。通过“找场景”，进一步深度挖掘传统产业发展潜力；通过“造场景”，激发新兴产业、未来产业的创新活力。第三，在人工智能产业发展中，要统筹发展和安全，坚持人工智能为人所用、为人服务、为人所控。要坚持人工智能国际合作、开放共享，团结世界各国的朋友们一起共同探讨，形成具有广泛共识的人工智能治理框架和规则，让人工智能更好造福人类，成为全球共同的“公共产品”。

科技部部长阴和俊在十四届全国人大四次会议首场“部长通道”上表示，我国科技事业快速发展，科技实力跃上新台阶，创新指数排名上升至全球第10。2025年，全社会研发投入超过3.92万亿元，强度达到2.8%。基础研究投入接近2800亿元，占比达7.08%，首次破7，创历史新高。阴和俊介绍，我国科技成果蓬勃发展，大量涌现。人形机器人在春节晚会上大放异彩，从去年的扭秧歌、转手绢到今年的翻跟头、演小品，十八般武艺竞相展示。开源大模型领跑全球，芯片攻关取得新突破，创新药迅猛发展，去年中国批准的创新药达到76个。对外授权交易的总额超过1300亿美金，科技赋能各行各业，有力提升人民生活品质。阴和俊表示，科技创新要瞄准产业需求，摆脱过去先有成果后转化的惯性思维，加快推动形成科技创新和产业创新一体谋划、一体部署、一体推动的格局，打通从科技强到产业强、经济强、国家强的通道。基于此，一要强化高质量科技供给，抓紧部署实施一批国家重大科技项目，为产业发展提供更强有力的科技支撑；二要强化企业科技创新的主体地位，加快培育壮大科技领军企业，要把更多的创新资源向企业集聚，要支持企业主导产学研融通创新，要支持企业牵头组建创新联合体，来承接更多攻关任务；三要进一步促进科技成果高效转化应用，要让更多的新技术、新产品有应用的场景；四要支持地方先行先试，引导其立足各地资源禀赋，锻造创新长板和特色产业。

有媒体援引知情人士消息，截至上月末，OpenAI年化收入突破250亿美元。据该人士及另一位知情人士称，这一数字较该公司年末214亿美元的年化收入增长了17%，而Anthropic正逐步缩小与OpenAI的收入差距。OpenAI日前发布了一款专为Windows设计的Codex应用，支持原生沙盒和PowerShell开发环境，该应用的Mac版本于一个月前发布。值得一提的是，英伟达CEO黄仁勋表示，向OpenAI投资1000亿美元的机会可能不会再出现了，“原因在于他们即将上市”。公司近期对OpenAI的300亿美元投资“可能是”在该公司在年底上市前对这家人工智能初创公司的最后一次投资。