Declaration of interests
JLC has provided consultation to Acadia, Actinogen, Acumen, AlphaCognition, ALZpath, Aprinoia, AriBio, Artery, Biogen, Biohaven, BioVie, Bio X Cel, Bristol-Myers Squib, Cassava, Cerecin, Diadem, Eisai, GAP Foundation, GemVax, Janssen, Jocasta, Karuna, Lighthouse, Lilly, Lundbeck, LSP/eqt, Merck, NervGen, New Amsterdam, Novo Nordisk, Oligomerix, OptoCeutics, Ono, Otsuka, Oxford Brain Diagnostics, Prothena, ReMYND, Roche, Sage Therapeutics, Signant Health, Simcere, Sinaptica, Suven, TrueBinding, Vaxxinity, and Wren pharmaceutical, assessment, and investment companies. He is supported by National Institute of General Medical Sciences grant P20GM109025, National Institute on Aging (NIA) grant R35AG71476, NIA grant R25 AG083721-01, Alzheimer's Disease Drug Discovery Foundation, Ted and Maria Quirk Endowment, and Joy Chambers-Grundy Endowment. AA has, in the last 10 years, served as a consultant or received honoraria or support for consulting; participating in independent data safety monitoring boards; providing educational lectures, programmes, and materials; and serving on advisory boards for AbbVie, Acadia, Allergan, Alzheimer's Disease International, the Alzheimer's Association, AriBio, Axovant, Axsome, AZTherapies, Biogen, Eisai, Grifols, Harvard Medical School Graduate Continuing Education, JOMDD, Johnson & Johnson, Life Molecular Imaging/Lantheus, Lundbeck, Merck, Michael J Fox Foundation, Novo Nordisk, ONO, Otsuka, Prothena, Qynapse, Roche/Genentech, Sunovion, Suven, Synexus, and Vaxxinity. He receives book royalties from Oxford University Press for a medical book on dementia. He receives institutional research grant or contract funding from the NIA/National Institutes of Health (NIH; 1P30AG072980, U24AG057437, 1P30AG072980, R01AG070883, R01AG086363, U01AG082350, U24AG057437), Arizona Department of Health Services (CTR040636), Foundation for the NIH, Washington University in St. Louis, Michael J. Fox Foundation, and Gates Ventures. His institution receives or has received funding for clinical trial grants, contracts, and projects from government, consortia, foundations, and companies, for which he serves or has served as a contracted site principal investigator. He has received or receives honoraria from Novo Nordisk for consulting activities, including for service on the evoke(+) program Steering Committee. MS has served on the Scientific Advisory Board for Medication and as a consultant for Eisai, Avenir, vTv, Biogen, Bio X Cel, F. Hoffman LaRoche, Merck, Novo Nordisk, Novartis, Otsuka, Genentech, and BioVie. She is a member of the Alzheimer Association Medical and Scientific Advisory Group and Chair of the data safety monitoring board for the Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease (SESAD; sponsor: University of Colorado). HZ reports a relationship with AbbVie, Acumen, Alector, Alzinova, ALZpath, Amylyx, Annexon, Apellis, Artery Therapeutics, AZTherapies, Cognito Therapeutics, CogRx, Denali, Eisai, Enigma, LabCorp, Merck Sharp & Dohme, Merry Life, NervGen, Novo Nordisk, Optoceutics, Passage Bio, Pinteon Therapeutics, Prothena, Quanterix, Red Abbey Labs, ReMYND, Roche, Samumed, ScandiBio Therapeutics AB, Siemens Healthineers, Triplet Therapeutics, and Wave that includes consulting or advisory services. He reports a relationship with AlzeCure, BioArctic, Biogen, Cellectricon, Fujirebio, LabCorp, Lilly, Novo Nordisk, Oy Medix Biochemica AB, Roche, and WebMD that includes speaking and lecture fees. He reports a relationship with Brain Biomarker Solutions in Gothenburg AB that includes equity or stocks. FKK, PJ, RMA, and CAW are employees and minor shareholders of Novo Nordisk. TL was an employee and minor shareholder of Novo Nordisk at the time of the analysis. PS is a full-time employee of EQT Life Sciences (formerly LSP) and Professor Emeritus at Amsterdam UMC. He is co-Chair of the Steering Committee for the phase 3 trials evoke and evoke+ with Novo Nordisk. HHF reports a consulting service agreement with Novo Nordisk for serving on the evoke + Steering Committee with funds including travel support for its meetings paid to UC San Diego. He receives no financial support for the present manuscript. Other disclosures include his receiving grants for UC San Diego from Allyx Therapeutics and Vivoryon Therapeutics (Probiodrug). He holds service agreements through UC San Diego for consulting with Biosplice Therapeutics, Arrowhead Pharmaceuticals, Axon Neuroscience, and LuMind Foundation. He provides service as a member of data and safety monitoring boards for Janssen Research & Development and Roche/Genentech and is a Scientific Advisory Board Chair for the Tau Consortium Rainwater Charitable Foundation through a UC San Diego service agreement. He has received travel support from Royal Society of Canada, Translating Research for Elder Care (TREC), Association for Frontotemporal Dementia (AFTD), Rainwater Charitable Foundation, Banner Health, Invictus, Summeet, and Novo Nordisk. He receives philanthropic support for Alzheimer's disease therapeutic research through the Epstein Family Alzheimer's Research Collaboration as well as personal funds for Detecting and Treating Dementia (Serial Number 12/3- 2691 US Patent Number PCT/US2007/07008, Washington DC, US Patent and Trademark Office).
